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Causes of IVF Failure
IVF

Causes of IVF Failure

It is not always possible to obtain successful results in IVF trials. The most important factor when evaluating IVF success rates is the age of the woman. Failure rates increase with age because genetic disorders are seen more frequently in eggs as women get older. However, even in young couples where everything appears normal, pregnancy may not occur despite IVF treatment.

Medical scientists recommend attempting IVF again after a failed cycle. The key is to learn from the first attempt and improve the second trial by carefully examining how that couple responded during the first cycle. In subsequent trials, the effects of the first attempt on egg development and embryo development are evaluated in detail.

IVF Failure Definition

Pregnancy cannot be achieved after 3 or more IVF applications despite transferring good quality embryos (10 or more).

Contributing Conditions

Conditions contributing to IVF failure include hydrosalpinx, intrauterine problems, myomas (fibroids), inadequate treatment protocols, coagulation factor issues, and genetic abnormalities. The approach involves reviewing treatment protocols, conducting genetic testing, assessing endocrinological status, personalizing new treatment options, and optimizing embryo transfer procedures with post-transfer support.

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IVF

Micro TESE

Male infertility affects approximately half of infertile couples. Micro TESE is an advanced sperm retrieval procedure performed under microscopic visualization.

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Frequently Asked Questions

Common Questions

Chromosomal abnormality of the embryo is the most common cause u2014 accounting for up to 60u201370% of failed implantations. These abnormalities increase with age. Preimplantation genetic testing (PGT-A) can identify chromosomally normal embryos and significantly improve success rates.

Yes. The endometrium must be receptive u2014 adequately thickened, well-vascularised, and in the correct developmental phase u2014 for implantation. ERA (Endometrial Receptivity Analysis) or EndomeTRIO testing can identify personalised transfer timing when repeated failures occur.

Embryo quality reflects genetic integrity and developmental potential. While grading systems predict success, even high-graded embryos can fail due to genetic abnormalities not visible morphologically. Extended culture to blastocyst stage selects the most competent embryos for transfer.

Age is the single most important factor in IVF outcome. Egg quality and quantity decline with age u2014 particularly after 37. This primarily reflects the increasing proportion of chromosomally abnormal eggs. For women over 40 with repeated failures, donor eggs offer substantially higher success rates.

After two or three failed cycles, a detailed review is warranted. This may include PGT-A testing of embryos, ERA/EndomeTRIO endometrial assessment, immunological screening, hysteroscopy to rule out uterine pathology, or u2014 in appropriate cases u2014 consideration of donor eggs or a different stimulation protocol.

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