IMSI and PICSI are advanced sperm-selection techniques used in IVF when sperm quality, morphology or DNA fragmentation is a concern. IMSI uses ultra-high magnification to choose sperm with the best structural integrity. PICSI selects mature sperm based on their natural ability to bind hyaluronic acid — closer to what occurs around the egg in nature. Dr. Muzaffer recommends these methods selectively, when they are likely to add real value to your cycle.
IVF
IMSI / PICSI — Advanced Sperm Selection
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Common Questions
Often after previous IVF failure, poor embryo development, recurrent miscarriage, or abnormal sperm morphology and DNA fragmentation results.
All three inject one sperm into the egg. IMSI adds higher magnification; PICSI adds biological selection based on maturity.
Yes. They are well-established laboratory techniques performed by experienced embryologists.
Not always. They add cost without value when standard sperm parameters are good. Dr. Muzaffer advises individually.
Yes, in selected cases the embryology team may combine elements of both for the best chance.
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